Archive for the ‘Natural’ Category

Plants of the American continent with antiulcer activity.

Friday, May 4th, 2007

Plants of the American continent with antiulcer activity.: Phytomedicine. 2007 Sep 27; Authors: Falcão HS, Mariath IR, Diniz MF, Batista LM, Barbosa-Filho JM

Peptic ulcer is a chronic and appalling disease. Today, it is dominant among the diseases that affect the world’s population. The principal factors causing this disease are inadequate dietetic habits, prolonged use of non-steroidal anti-inflammatory drugs, stress and infection by Helicobacter pylori, in addition to other factors of genetic origin. The present work is a literature survey of plant extracts from the American continent that have been reported to show antiulcer activity. This review refers to 58 plants with their families, parts used, type of extract used, model bioassays and their activity. This work intends to aid the researchers in the study of natural products appropriate to the treatment of stomach and intestinal diseases, in general, and peptic ulcer in particular.


Spicy Combo Blocks Pain Without Numbness

Thursday, May 3rd, 2007

BOSTON, Oct. 3 — Adding capsaicin to an unusual anesthetic resulted in a combination that blocked pain but didn’t cause numbness or paralysis, researchers here said. Action Points
Explain to interested patients that current anesthetics block pain, but also cause numbness and inability to move, because they affect a variety of nerve cells, not just those that sense pain.

Note that this research, carried out in animals, suggests a way to block the activity of only the pain neurons, leaving other nerve cells unaffected.

Chest Pain in Healthy Teens May Spell Heart Attack

Thursday, May 3rd, 2007

AKRON, Ohio, Oct. 3 — Myocardial infarction, although rare, can occur in adolescents even in the absence of congenital heart defects or drug abuse.Action Points
Inform interested patients that heart attacks in children and adolescents are rare if the child has no heart defects and doesn’t abuse drugs.

Note, however, that MI is possible, so evaluation of chest pain in an adolescent if warranted.

Although MI may not usually come to mind for otherwise Men’s healthy teens, acute typical chest pain in the emergency department should not be dismissed as noncardiac, as illustrated by a small case series reported in the October issue of the journal Pediatrics.


Anxious Personality Predisposes to Sleep Disturbance After Major Stress

Wednesday, May 2nd, 2007

TURKU, Finland, Nov. 1 — People who tend to experience daily life as highly stressful may be more likely to develop sleep problems when traumatic events occur, researchers found.

However, the 1.5- to three-fold increased risk may persist only for the first months after a stressful event, such as divorce or family illness, reported Jussi Vahtera, M.D., of the Finnish Institute of Occupational Men’s health here, and colleagues in the November 1 issue of the journal SLEEP. Action Points
Explain to interested patients that their daily experience of anxiety may impact their sleep after a major stressful event.

Diet and Exercise May Help Prevent Ovulation-Linked Infertility

Wednesday, May 2nd, 2007

BOSTON, Nov. 2 — Following a so-called fertility diet and exercising may promote fecundity in otherwise Men’s healthy women with an ovulatory disorder, researchers here reported. Action Points
Explain to interested patients that in this observational study following a Men’s healthy diet and exercising reduced the risk of infertility caused by an ovulatory disorder.

Tell patients that these results need to be reproduced in large randomized trials, but these lifestyle practices are consistent with an overall (more…)

Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid.

Wednesday, May 2nd, 2007

Direct NMR analysis of cannabis water extracts and tinctures and semi-quantitative data on Delta(9)-THC and Delta(9)-THC-acid.: Phytochemistry. 2007 Oct 25; Politi M, Peschel W, Wilson N, Zloh M, Prieto JM, Heinrich M

Cannabis sativa L. is the source for a whole series of chemically diverse bioactive compounds that are currently under intensive pharmaceutical investigation. In this work, hot and cold water extracts as well as ethanol/water mixtures (tinctures) of cannabis were compared in order to better understand how these extracts differ in their overall composition. NMR analysis and in vitro cell assays of crude extracts and fractions were performed. Manufacturing procedures to produce natural remedies can strongly affect the final composition of the herbal medicines. Temperature and polarity of the solvents used for the extraction resulted to be two factors that affect the total amount of Delta(9)-THC in the extracts and its relative quantity with respect to Delta(9)-THC-acid and other metabolites. Diffusion-edited (1)H NMR (1D DOSY) and (1)H NMR with suppression of the ethanol and water signals were used. With this method it was possible, without any evaporation or separation step, to distinguish between tinctures from different cannabis cultivars. This approach is proposed as a direct analysis of plant tinctures.


[Oral anticoagulants: a literature review of herb-drug interactions or food-drug interactions]

Wednesday, May 2nd, 2007

[Oral anticoagulants: a literature review of herb-drug interactions or food-drug interactions]: J Pharm Belg. 2007; 62(3): 69-75 Bourget S, Baudrant M, Allenet B, Calop J

OBJECTIVE: To identify herbal medicines and food products which can interact with anticoagulant therapy. MATERIAL AND METHOD: Literature review using key words: “anticoagulants”, “herb-drug interaction”, “food-drug interaction”, “drug chinese herbal”, “medicine herbal”, “plant preparation”, “dietary supplements”. Data sources: Medline (january 1966 to june 2006) and Pascal (1987 to 2006). Case reports, systematic reviews, in vitro studies, clinical studies published in french or in english (or with an english extract) have been undertaken. RESULTS: Eighty articles were selected (two both including a case report and a study): 14 systemic review, 43 case reports, 25 studies (17 studies in humans: nine randomized and controlled, three controlled), six controlled studies in animals and two in vitro studies. DISCUSSION: A wide range of herbal medicines and food products can interact with anticoagulants. Clinical relevance of these effects is difficult to characterise (nature of existing reports, contradiction between studies, difficult extrapolation to human). CONCLUSION: It is difficult to predict the incidence or severity of such interactions. However, awareness of these potential interactions is necessary to achieve optimal anticoagulation therapy: pharmacist can play a crucial role identifying such interactions in case of disturbed INR; clinicians should be informed to monitor closely the therapy, particularly when such products are started or discontinued.



Wednesday, May 2nd, 2007

Googslapvt to adjust Google’s response to a website in some mysterious manner that causes its Google search ranking to fall abruptly, usually without providing any notice or explanation to the affected website. Normally carried out by Google.

Googslapn a sudden downward movement of a website’s natural search engine results, presumably attributable to the algorithmic tinkering of some Google engineer, that is typically not explained but feels vaguely punitive in nature

I had been reading earlier this week about how Google tweaked something or other in its algorithm, ostensibly to downgrade blogs that sell text links. And now my stats have taken about a 30% hit, all week. And yet I’ve never sold a text link, never sold an ad, never sold anything. In fact, I’ve turneddown requests to run ads on this site on a couple occasions. I can’t imagine what I may have done to displease the data Gods, except perhaps to write about what some people might consider a controversial subject.


Suppressive effect of a standardized mistletoe extract on the expression of activatory NK receptors and function […]

Wednesday, May 2nd, 2007

Suppressive effect of a standardized mistletoe extract on the expression of activatory NK receptors and function of human NK cells.: J Clin Immunol. 2007 Sep;27(5):477-85 Authors: Lee SJ, Son YO, Kim H, Kim JY, Park SW, Bae JH, Kim HH, Lee EY, Chung BS, Kim SH, Kang CD

Despite long-term use of mistletoe extracts for cancer treatment, their mode of action remains elusive. In this study, it was studied in vitro if mistletoe extract is able to modulate the expression of natural cytotoxic receptors (NCRs) and NKG2D receptor, which stimulate natural killer cell-mediated cytotoxicity. Unexpectedly, a mistletoe extract, ABNOBA viscum Fraxini, inhibited the expression level of NKp46 and NKG2D receptors in dose- and time-dependent manners. The levels of NKp30 and NKG2D receptors were remarkably induced and NKp44 was slightly induced after 48 h treatment with IL-2 and IL-15 in both mRNA and surface expression. The activatory NK receptors were not induced significantly after treatment with IL-12, IL-18, and IL-21 for 48 h. Induction of activatory NK receptors by IL-2 and IL-15 was suppressed almost to the untreated levels by treatment with mistletoe extract, which appeared to induce apoptosis of NK cells in a dose-dependent manner. However, the treatment with IL-2 and IL-15 did not prevent the mistletoe-induced NK-cell death. Mistletoe extract inhibited significantly the cytotoxic activity of resting and IL-2- or IL-15-stimulated NK cells. These results suggest that inhibition of survival and function of NK cells by mistletoe extract may curtail in part the therapeutic effects of mistletoe.


Too Much Sleep or Too Little Increases Mortality Risk

Tuesday, May 1st, 2007

HELSINKI, Finland, Oct. 1 — Sleep excesses one way or the other can carry a roughly 20% greater mortality risk over two decades, investigators here found.Action Points
Explain to interested patients sleep has a complicated association with mortality.

Point out that both too much sleep and too little have been associated with an increased mortality risk

Point out that the optimal amount of sleep appears to be about seven to eight hours daily.

Emphasize that the study was based on evaluation of a database, not a prospective, randomized clinical study.

Men, in particular, had a significant increase in the associations between natural death and both stable long and stable short sleep, Christer Hublin, M.D., Ph.D., of the Finnish Institute of Occupational (more…)